Short bio

WORK

I. Research collaborations

  1. Tel-Aviv University, Dept. of Biochemistry & Molecular Biology (Prof. Nir Ben-Tal’s group) – structure-function relationship in proteins and peptides.
  2. The Hebrew University of Jerusalem, Institute of Chemistry (Prof. Uri Raviv’s group) – experimentally-guided protein structure prediction.

 

II. Industry

Co-founder and Head of Innovative R&D at Es-is Technologies Ltd (2010- 2014)

Es-is used computational methods to design chemo-enzymatic processes for the pharmaceutical industry. These processes were used to synthesize active pharmaceutical ingredients/intermediates in a way which was more efficient and environmentally friendly than the existing methods.

 

III. Teaching & course development

  1. Structural biology (graduate level) – Tel-Aviv University (Faculty of Biochemistry & Molecular Biology).
  2. Biochemistry 101 for chemistry students (undergraduate level) – Tel-Aviv University (Faculty of Biochemistry & Molecular Biology).
  3. Biochemistry 101 for medical students (undergraduate level) – Tel-Aviv University (Faculty of Biochemistry & Molecular Biology).
  4. Biochemistry 101 for nursing students (undergraduate level) – Tel-Aviv-Yaffo Academic College (Nursing school).
  5. Proteins: Structure & Function (undergraduate level) – Tel-Aviv-Yaffo Academic College (Bioinformatics dept.)

 

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 PUBLICATIONS

I. Books

  • Kessel, A. and Ben-Tal, N. (In preparation) Proteins: Structure, Function, & Motion. 2nd edition. (textbook).Publisher: CRC press (Taylor & Francis LLC.).
  • Kessel, A. and Ben-Tal, N. (2010) Proteins: Structure, Function, & Motion. 1st edition. (textbook).Publisher: CRC press (Taylor & Francis LLC.). [amazon.com]

II. Articles

  • Kessel, A., Kolodny, R., and Ben-Tal, N. Similarity between the repeating domain of an ice-adhesin and usher plug: evolution via surface reshaping. Isr. J. Chem. 57: 381-384 (PDF)
  • Glaser, F., Rosenberg, Y., Kessel, A., Pupko, T. and N. Ben-Tal (2005) The ConSurf-HSSP database: The mapping of evolutionary conservation among homologs onto PDB structures. PROTEINS: Structure, Function, and Bioinformatics 58:610-617. [PDF]
  • Oren, I., Fleishmann, S.J., Kessel, A. and N. Ben-Tal (2004) Free Diffusion of Steroid Hormones Across Biomembranes: A Simplex Search with Implicit Solvent Model Calculations. Biophys. J. 87:768-779. [PDF]
  • Kessel, A., Tieleman, D. P. and N. Ben-Tal (2004) Interactions of alamethicin channels with lipid bilayers: continuum solvent model studies of structures derived from molecular dynamics simulations. European. Biophysics. J. 33:16-28. [PDF]
  • Kessel, A., Shental-Bechor, D., Haliloglu T. and N. Ben-Tal (2003) Interactions of the M2δ segment of the acetylcholine receptor with lipid bilayers: Monte Carlo simulations. Biophys. J. 85: 3431-3444. [PDF]
  • Kessel, A., Shental-Bechor, D., Haliloglu, T.and N. Ben-Tal (2003) Interactions of the M2δ segment of the acetylcholine receptor with lipid bilayers: continuum solvent model studies. Biophys. J. 85: 3687-3695. [PDF]
  • Kessel, A. and N. Ben-Tal (2002) Free energy determinants of peptide association with lipid bilayers. In Current Topics In Membranes. 52: 205-253. S. A. Simon and T. J. McIntosh, editors. ).Publisher:Academic Press. (Also published in: ChemInform. 33 (43): 292-292 (ISSN: 1522-2667)). [PDF]
  • Bransburg-Zabary, S., Kessel, A., Gutman, M. and N. Ben-Tal. (2002) Stability of an ion channel in lipid bilayers: implicit solvent model calculations with gramicidin. Biochemistry 41: 6946-6954. [PDF]
  • Kessel, A., Ben-Tal, N. and S. May. (2001) Interactions of cholesterol with lipid bilayers: the preferred configuration and fluctuations.  Biophys. J. 81: 643-658. [PDF]
  • Kessel, A., Musafia, B. and N. Ben-Tal (2001) Continuum solvent model studies of the interactions of an anticonvulsant drug with lipid bilayers. Biophys. J. 80: 2535-2545. [PDF]
  • Kessel, A., Schulten, K. and N. Ben-Tal (2000) Calculations suggest a pathway for the transmembrane migration of a hydrophobic peptide. Biophys. J. 79: 2322–2330. [PDF]
  • Kessel, A., Cafiso, D. S. and N. Ben-Tal (2000) Continuum solvent model calculations of alamethicin-membrane interactions: thermodynamic aspects. Biophys. J. 78: 571-583. [PDF]

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